Mystery of the Crooked Cell is an activity developed by Learning Undefeated to help students explore genetic diseases and tracing genetics through the use of Punnett squares and gel electrophoresis.
Sickle cell anemia is a hereditary disease that is passed down to an individual from their parents. The disease causes red blood cells to form into an abnormal crescent shape, which prevents the cells from efficiently carrying oxygen to the body’s tissues.
Students will be able to
- Illustrate how amino acids interact to create a protein
- Identify an enzyme’s specific substrate
- Recognize the symptoms of sickle cell anemia and hemoglobin’s role in the disease
- Differentiate between a patient with sickle cell anemia and a patient without sickle cell anemia using gel electrophoresis
- Calculate the probability of an offspring having a specific phenotype using a Punnett square
- Analyze a pedigree to track a gene through a family
- Show how a point mutation can change the function of a protein