Last Updated Dec 1, 2020
This unit will introduce students to lactose intolerance. Students will develop questions about a case of a girl with symptoms of stomach pains, gas, and diarrhea. Throughout the unit, students will analyze pieces of evidence to answer their questions and eventually come to understand the mechanism of lactose intolerance.
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Students will know
- Carbohydrates (monosaccharides and polysaccharides)
- Mutations in a gene can change gene function
- Mutations in regulatory regions can change gene expression
- Enzyme substrate relationship
Students will understand
- Monosaccharides are building blocks of polysaccharides
- Enzymes can break down polymers into monomers
- Enzymes are specific to a substrate
- Gene expression is regulated
Students will be able to
- Analyze data to determine if Maria had an allergic reaction
- Analyze data to determine milk types based on glucose data and response to specific enzymes
- Analyze RT-PCR data to determine the expression of LCT in Maria
- Collect data about lactase’s activity in different environments to determine where in the body lactase is usually expressed.
Next Generation Science Standards Connections
HS-LS3-1: Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions of characteristic traits passed from parents to offspring.
Texas Essential Knowledge and Skills Connections
B.6D: recognize that gene expression is a regulated process
B.6E: identify and illustrate changes in DNA and evaluate the significance of these changes